Nephrology is a medical specialty focused on kidney and the diagnosis, color of urine, treatment, and management of kidney diseases and related disorders. Nephrologists, the doctors who practice nephrology, address conditions such as chronic-kidney disease, acute-kidney injury, glomerulonephritis, hypertension related to kidney issues, and electrolyte imbalances. They are also involved in the management of patients requiring dialysis and kidney transplantation. Nephrologists perform a variety of diagnostic tests, including blood and urine tests, kidney biopsies, and imaging studies. Treatment strategies often involve medications, lifestyle changes, and, in severe cases, dialysis or transplantation. Nephrology also overlaps with other medical disciplines, given the kidney's role in regulating blood pressure, red blood cell production, and overall homeostasis. This field is crucial in improving and upgrading the quality of lifespan and survival rates for patients with kidney-related illnesses.
The kidneys are vital organs with several critical functions that maintain the body's overall health and homeostasis. Each kidney performs the following key roles
The kidneys play a pivotal role in blood purification, filtering out waste products and surplus substances to maintain bodily balance. Within the kidneys, nephrons act as the essential units, sieving blood as it passes through
The kidneys help regulate blood pressure through the renin-angiotensin-aldosterone-system (RAAS). They release the enzyme renin, which activates a cascade of hormones that adjust blood vessel constriction and sodium and water balance, thus controlling blood pressure.
The kidneys maintain the balance of critical electrolytes such as sodium, potassium, calcium, and phosphate in the blood. They achieve this by filtering these electrolytes and either reabsorbing the necessary amounts back into the bloodstream or excreting excess quantities in the urine.
The kidneys help regulate the body's pH level by excreting hydrogen ions and reabsorbing bicarbonate from urine. This function is crucial in maintaining the acid-base balance, preventing conditions like acidosis or alkalosis.
The kidneys remove metabolic waste products from the bloodstream, including urea (from protein metabolism), uric acid (from nucleic acid metabolism), and creatinine (from muscle metabolism). These waste products are excreted/pass in the urine.
The kidneys regulate the body's fluid balance/footing by adjusting the amount of water excreted in the urine. This function helps maintain optimal hydration levels and blood volume.
Erythropoietin is a hormone secreted by the kidneys that causes the bone marrow to produce red blood cells. Particularly when blood oxygen levels are low, this mechanism is essential for avoiding anemia
The kidneys help detoxify the body by excreting drugs, toxins, and other harmful substances. They play a critical role in metabolizing and eliminating these compounds from the bloodstream.
The kidneys convert inactive vitamin D into its active form, calcitriol. Active vitamin D is essential and crucial for calcium absorption in the intestines and for maintaining healthy bones.
The kidneys contribute to glucose production during periods of prolonged fasting or starvation by performing gluconeogenesis, the process of synthesizing glucose from noncarbohydrate sources.
A long-term condition where the kidneys gradually/slowly lose function over time. It's often caused by diabetes, high blood pressure, and other chronic conditions.
Acute kidney injury (AKI) is a rapid decline in your kidneys' ability to function, happening within hours or days. This sudden drop disrupts waste removal from your blood, leading to a build-up of toxins and potentially harming other organs
inflammation of the kidney's microscopic filtering units, called glomeruli. Infections, autoimmune disorders, or other underlying medical issues may be the cause of this syndrome.
an inherited condition marked by the development of many kidney cysts. The kidneys may get larger and less functional as a result of these cysts.
Hard deposits made of minerals and salts that form inside the kidneys. Kidney stones can cause severe pain and create lot of trouble may lead to infection or kidney damage if not treated.
Infections that affect the urinary system, including the kidneys (pyelonephritis). If left untreated, UTIs can lead to kidney damage.
Diabetes-related renal damage. Over time, high blood sugar levels might impair the kidneys' ability to filter substances
renal damage brought on by long-term excessive blood pressure. The elevated pressure may harm the kidneys' blood arteries, impairing their capacity to operate as intended.
A group of symptoms indicating kidney damage, including proteinuria (high levels of protein in the urine), hypoalbuminemia (low blood albumin levels), and edema (swelling).
Inflammation of the kidney's interstitial tissue, which surrounds the nephrons. This can be caused by infections, medications, or autoimmune diseases
A genetic disorder characterized by kidney disease, hearing loss, and eye abnormalities. It affects the basement membranes in the kidneys, ears, and eyes
Kidney inflammation caused by systemic lupus erythematosus (SLE), an autoimmune disease. The immune system may attacks the kidneys, leading to inflammation and damage.
A disorder causing nephrotic syndrome, primarily seen in children. Despite severe symptoms, the kidneys appear normal under a regular microscope
Scarring in parts of the kidneys' glomeruli, which can lead to nephrotic syndrome and progressive kidney damage
A condition in which amyloid proteins build up in organs, including the kidneys, impairing their function.
A rare autoimmune disease where antibodies attack the kidneys and lungs, leading to bleeding in the lungs and glomerulonephritis.
A congenital disorder where cysts form in the tubules within the kidneys, often leading to kidney stones and infections
Narrowing of the arteries that supply blood to the kidneys, often caused by atherosclerosis, leading to high blood pressure and reduced kidney function
Swelling of a kidney due to a buildup of urine, which can be caused by a blockage in the urinary tract
A rare kidney cancer primarily affecting children, also known as nephroblastoma.
Diet: Low sodium, low protein diets to reduce kidney workload. Exercise: Regular physical activity to manage blood pressure and diabetes. Smoking Cessation: To improve overall health and slow disease progression
Blood Pressure Control: ACE inhibitors or ARBs to manage hypertension. Diabetes Management: Medications like insulin or metformin to control blood sugar levels. Cholesterol-Lowering Drugs: Statins to reduce cardiovascular risk
Hemodialysis: Blood is filtered outside the body using a machine. Peritoneal Dialysis: The lining of the abdomen (peritoneum) filters blood inside the body
Surgical procedure to replace a diseased kidney with a healthy donor kidney
Fluids and Electrolytes: Intravenous fluids to address dehydration or shock. Medications: To treat infections or manage underlying conditions like heart failure.
Temporary measures to remove toxins and support kidney function during recovery.
Regular monitoring of kidney function and supportive measures to prevent complications.
Corticosteroids: To reduce inflammation. Immunosuppressants: To control the immune response. Antibiotics: If infection is the cause.
Low-sodium diet to control blood pressure. Fluid restrictions in severe cases
In severe or advanced cases where kidney function is critically impaired.
Over-the-counter pain relievers (avoiding NSAIDs, which can harm kidneys).
Blood Pressure Control:
ACE inhibitors or ARBs to manage hypertension.
Dialysis or Transplant:
In advanced stages, kidney function is severely reduced.
Pain relievers to manage symptoms. Alpha-blockers to help pass stones
Increased fluid intake to flush out stones.
Extracorporeal Shock Wave Lithotripsy (ESWL): Using shock waves to break up stones. Ureteroscopy: Using a scope to remove stones. Percutaneous Nephrolithotomy: Removing large stones via a small incision in the back
Antibiotics are prescribed based on the type of bacteria causing the infection
Hydration:
Increased the fluid intake to help flush out bacteria
Blood Sugar Control: Medications such as insulin or oral hypoglycemics.
Blood Pressure Control: ACE inhibitors or ARBs.
Lifestyle Changes: Healthy diet, regular exercise, and smoking cessation.
ACE inhibitors or ARBs to control blood pressure. Diuretics to reduce fluid overload
Low-sodium diet, weight management, and regular exercise.
Corticosteroids and immunosuppressants to reduce proteinuria. Diuretics to manage edema
Low-sodium, low-protein diet to reduce kidney strain.
Discontinuing the offending drug or treating the infection.
Corticosteroids to reduce inflammation.
Corticosteroids and other immunosuppressants like cyclophosphamide or mycophenolate mofetil.
ACE inhibitors or ARBs
To remove harmful antibodies from the blood
Medications to suppress the immune system.
Office or other outpatient visit for the E&M of a patient with kidney-related issues, varying by complexity and level of service provided
Dialysis procedures, including hemodialysis and peritoneal dialysis, as well as related management and monitoring services.
Kidney transplant procedures, including donor nephrectomy and recipient nephrectomy.
Kidney biopsy procedures, including percutaneous and open approaches, with or without imaging guidance
Diagnostic ultrasound of the kidneys and renal vessels
Comprehensive metabolic panel and individual electrolyte tests, including sodium, potassium, chloride, and bicarbonate
Laboratory tests to assess renal function, including serum creatinine, blood urea nitrogen (BUN), and glomerular filtration rate (GFR).
Total hip arthroplasty.
This procedure, also known as hip replacement surgery, involves replacing a damaged main hip joint with a prosthetic implant.
Ambulatory blood pressure monitoring and related services.
Procedures for the placement, revision, or removal of vascular access devices for hemodialysis, including arteriovenous fistulas and grafts
Diagnostic and interventional procedures for renal artery angiography, including angioplasty and stent placement
Management and monitoring services for home dialysis patients, including peritoneal dialysis and home hemodialysis
Ultrasound guidance for renal or peritoneal dialysis access procedures
Computed tomography (CT) and magnetic resonance imaging (MRI) procedures for renal imaging and evaluation
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